The German surname Setzer is an Upper German name with roots in the southern region of Bavaria. The name is derived from the German verb "setzen," meaning "to set," and was probably first borne by someone who worked at a market or fair, setting the prices of merchandise. The Low German variation of the name, Settegast, is even more specific, meaning "one who sets the price of barley." (info from 'House of Names')
The surname Setzer was first found in Regensburg; the first recorded bearer was Ortlieb der Setzer, who lived there in 1290. The young Setzer family was instrumental during this early period, playing a major role in the development of medieval Bavarian society. (info from 'House of Names')
A class of old German citizens from the 16th century, natives of the Preuben province, residing in Eberswalde (Wild Boar Woods or Forest). There is also listed, that the Lt. & Commander of an infantry troop, Herman August Setzer, in 1654, was distinguished for his great value to the Nation of the Prussian king's authority with the Medal of Valor, 1st Class and with paper of nobility in Pergament. [info from John Lee Setzer, Sr.'s book, Setzer Setser Genealogy]
Below or some Setzer's or close spelling, of those arriving in the new world about the same time.